CMH-Small Molecule Docks into SIRT1, Elicits Human IPF-Lung Fibroblast Cell Death, Inhibits Ku70-deacetylation, FLIP and Experimental Pulmonary Fibrosis

Regenerative capacity in vital organs is limited by fibrosis propensity.Idiopathic pulmonary fibrosis (IPF), a progressive lung disease here linked with aging, is a classic example.In this study, we show that in flow cytometry, immunoblots (IB) and in lung sections, FLIP levels can be regulated, in vivo and in vitro, through SIRT1 activity inhibiti

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